Zonulin（连蛋白）是一种参与上皮和内皮屏障功能调节的蛋白质，对肠粘膜细胞紧密连接的调节对于维持屏障内环境的平衡至关重要，zonulin是目前唯一已知的细胞间紧密连接的生理调节剂，参与大分子的运输和耐受/免疫反应平衡。当连蛋白与肠的上皮细胞结合时，会诱导信号级联。这种级联分解了肠壁的细胞旁紧密连接。肠壁的紧密连接是允许分子从肠腔转移到血流的两种方式之一，反之亦然。当肠道中的连蛋白水平增加并失去平衡时，这些连接点会打开得更宽，并保持更长时间。这些加宽的入口点允许较大的大分子进入血液或肠腔。通过这些缺口的分子可以增加身体的自然免疫反应，引起炎症和一些自身免疫性疾病。

与 Zonulin 水平升高相关的疾病：

• 1型糖尿病

• 类风湿关节炎

• 乳糜泻

• 肝病

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* Immundiagnostik荣誉出品..仅供科研使用，不得用于医疗.

Zonulin产品已发表文章：

• Parker, Jim, Claire O’brien, and Jason Hawrelak. "A narrative review of the role of gastrointestinal dysbiosis in the pathogenesis of polycystic ovary syndrome." Obstetrics & Gynecology Science 65.1 (2022): 14-28.

• Kleppe, Malin M., et al. "Intestinal barrier integrity in anorexia nervosa (a pilot study)." International Journal of Eating Disorders (2022).

• Meira de-Faria, Felipe, et al. "Colonic paracellular permeability and circulating zonulin-related proteins." Scandinavian Journal of Gastroenterology 56.4 (2021): 424-431.

• Tatucu-Babet, Oana A., et al. "Serum zonulin measured by enzyme-linked immunosorbent assay may not be a reliable marker of small intestinal permeability in healthy adults." Nutrition Research 78 (2020): 82-92.

• Xu, Yiyi, et al. "Inflammatory bowel disease and biomarkers of gut inflammation and permeability in a community with high exposure to perfluoroalkyl substances through drinking water." Environmental Research 181 (2020): 108923.

• Scherf, Katharina Anne, et al. "Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers." Clinical and translational allergy 9.1 (2019): 1-12.

• Kanerva, Sonja. "Assessment of immunological methods for quantification of human zonulin and the effects of intestinal bacteria on zonulin secretion in vitro." (2019).

• Ajamian, Mary, et al. "Serum zonulin as a marker of intestinal mucosal barrier function: May not be what it seems." PloS one 14.1 (2019): e0210728.

• Shariatpanahi, Zahra Vahdat, et al. "Effects of early enteral glutamine supplementation on intestinal permeability in critically ill patients." Indian Journal of Critical Care Medicine: Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine 23.8 (2019): 356.

• Scheffler, Lucas, et al. "Widely used commercial ELISA does not detect precursor of haptoglobin2, but recognizes properdin as a potential second member of the zonulin family." Frontiers in endocrinology 9 (2018): 22.

• Mokkala, K., et al. "Evaluation of serum zonulin for use as an early predictor for gestational diabetes." Nutrition & diabetes 7.3 (2017): e253-e253.